Langerhans Cell Histiocytosis: A Case Report And Update On Treatment Modalities
DOI:
https://doi.org/10.22452/adum.vol3no1.9Keywords:
Langerhans cell histiocytosis, Letterer-Siwe disease, Birbeck's granulesAbstract
Various treatment modalities exist for Langerhans cell histiocytosis(LCH) due to its uncertain aetiology.. LCH patients are clinically divided into a single and multisystem group and each group warrants a different approach to treatment. However, histologically, CD Ia antigen and Birbeck's granules have been implicated in both types of the disease. This article therefore describes clinical presentations of different forms of the disease and the treatments contrived for them. The single system group is treated conservatively with either curettage of the localised lesion, intralesional steroid injection or in some cases radiotherapy. For the multisystem group, treatment consists of chemotherapeutic agents as either a single or combination therapy.
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