EFFECTS OF VITAMIN E ON COLORECTAL CANCER: A SYSTEMATIC REVIEW OF THE RECENT IN VITRO AND IN VIVO EXPERIMENTAL STUDIES
Received 2022-12-05; Accepted 2023-02-18; Published 2023-06-06
Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. Although with advanced medical insight and care, patients with late-stage CRC have a poor prognosis due to a lack of efficient therapy. Numerous scientific studies on the effects of vitamin E on cancer have been undertaken over the last few decades, with mixed findings. Thus, the goal of this review was to compile and summarize the data on vitamin E in vivo and in vitro experimental trials. PubMed, Scopus, and Science Direct databases were used for automated search of the literature spanning the period from 2010 to February 2021 using the following keywords: vitamin E or tocopherol or tocotrienol; and colorectal cancer or colorectal carcinogenesis or colorectal tumorigenesis. The findings obtained from the ten selected papers on vitamin E, in both in vitro and in vivo models, exhibited the positive effects of vitamin E on colorectal carcinogenesis, thus, necessitating further research on the notable isomers and metabolites of this compound.
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