EFFECTS OF VITAMIN E ON COLORECTAL CANCER: A SYSTEMATIC REVIEW OF THE RECENT IN VITRO AND IN VIVO EXPERIMENTAL STUDIES

Received 2022-12-05; Accepted 2023-02-18; Published 2023-06-06

Authors

  • Norul Hasliza Shams Hashim Department of Toxicology, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Penang, Malaysia.
  • Nor Adlin Md Yusoff Department of Toxicology, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Penang, Malaysia.
  • Sharlina Mohamad Department of Toxicology, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Penang, Malaysia.
  • Siti Nurfatimah Mohd Shahpudin Department of Toxicology, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Penang, Malaysia.
  • Thayvee Geetha Bharathi Silvaragi Department of Toxicology, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Penang, Malaysia.
  • Siti Nazmin Saifuddin Department of Toxicology, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Penang, Malaysia.

DOI:

https://doi.org/10.22452/jummec.sp2023no1.7

Abstract

Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. Although with advanced medical insight and care, patients with late-stage CRC have a poor prognosis due to a lack of efficient therapy. Numerous scientific studies on the effects of vitamin E on cancer have been undertaken over the last few decades, with mixed findings. Thus, the goal of this review was to compile and summarize the data on vitamin E in vivo and in vitro experimental trials. PubMed, Scopus, and Science Direct databases were used for automated search of the literature spanning the period from 2010 to February 2021 using the following keywords: vitamin E or tocopherol or tocotrienol; and colorectal cancer or colorectal carcinogenesis or colorectal tumorigenesis. The findings obtained from the ten selected papers on vitamin E, in both in vitro and in vivo models, exhibited the positive effects of vitamin E on colorectal carcinogenesis, thus, necessitating further research on the notable isomers and metabolites of this compound.

Downloads

Download data is not yet available.

Downloads

Published

2023-06-06

Issue

Special Issue 1 (2023) Complementary Therapy, Diagnostic and Advanced Material in Medical and Dentistry

Section

Research article

License

All authors agree that the article, if editorially accepted for publication, shall be licensed under the Creative Commons Attribution License 4.0 to allow others to freely access, copy and use research provided the author is correctly attributed, unless otherwise stated. All articles are available online without charge or other barriers to access. However, anyone wishing to reproduce large quantities of an article (250+) should inform the publisher. Any opinion expressed in the articles are those of the authors and do not reflect that of the University of Malaya, 50603 Kuala Lumpur, Malaysia.