A NETWORK PHARMACOLOGY APPROACH TO EXPLORE CLINACANTHUS NUTANS ON COLORECTAL CANCER

Received 2023-01-19; Accepted 2023-03-10; Published 2023-06-06

Authors

  • Ahmed Abdulla Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, 13200 Kepala Batas, Penang, Malaysia.
  • Vuanghao Lim Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, 13200 Kepala Batas, Penang, Malaysia.

DOI:

https://doi.org/10.22452/jummec.sp2023no1.8

Abstract

Network pharmacology is a discipline that investigates traditional herbal medications using bioinformatic tools like chemical, protein, gene, and disease databases, and cytoscape, by visualizing the complex network of interactions between the chemical constituents in the medications and their targets. Clinacanthus nutans (CN) is a traditionally used medicinal herb that has been suggested for its role in cancer treatment. The current study investigated the network pharmacology of CN bioactives as a prospect for the treatment of colorectal cancer. A series of database mining steps were performed to create lists of bioactives, their targets, and target-related diseases. The network was constructed using cytoscape. In this study, 8 bioactives, i.e. β-amyrin, betulin, isovitexin, linolenyl alcohol, lupeol, orientin, palmitic acid, vitexin) were identified which interacted with 46 different targets. β-amyrin was identified as the most potent bioactive with 29 targets.

Downloads

Download data is not yet available.

Downloads

Published

2023-06-06

Issue

Special Issue 1 (2023) Complementary Therapy, Diagnostic and Advanced Material in Medical and Dentistry

Section

Research article

License

All authors agree that the article, if editorially accepted for publication, shall be licensed under the Creative Commons Attribution License 4.0 to allow others to freely access, copy and use research provided the author is correctly attributed, unless otherwise stated. All articles are available online without charge or other barriers to access. However, anyone wishing to reproduce large quantities of an article (250+) should inform the publisher. Any opinion expressed in the articles are those of the authors and do not reflect that of the University of Malaya, 50603 Kuala Lumpur, Malaysia.