The Role of The EphrinB2-EphB4 Bidirectional Signalling on Bone Remodeling: A Review

Authors

  • Zhou Qinghui School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise, 533000 Guangxi, P.R. China https://orcid.org/0009-0003-8916-4115
  • Chew Weiyun Department of Biochemistry, Faculty of medicine, bioscience and Nursing, MAHSA University, 42610 Jenjarom, Malaysia
  • Tang Hanqing School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise, 533000 Guangxi, P.R. China
  • Suresh V Chinni Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, 602105 Chennai, India

DOI:

https://doi.org/10.22452/mjs.vol44sp1.1

Keywords:

EphrinB2, EphB4, Bone remodeling, Osteoclast, Osteoblast

Abstract

Postmenopausal osteoporosis is a prevalent disease that can lead to serious outcomes such as fractures. Oestrogen deficiency during menopause and postmenopause increases bone turnover, with elevated bone resorption and formation. However, resorption surpasses formation, resulting in bone loss. Identifying intervention targets in bone physiology to restore bone remodeling balance and normal bone mass is the initial aim in developing new effective therapies. Currently, EphrinB2/EphB4, one of the membrane coupling factors between osteoclasts (OCs) and osteoblasts (OBs), is a prominent topic in bone disease research. However, the regulatory mechanisms of EphrinB2-EphB4 bidirectional signalling on OC and OB and its effects remain incompletely understood. This review seeks to clarify the physiological roles and mechanisms of known EphrinB2-EphB4 bidirectional signalling in bone remodeling, providing insights for future studies on modulating this signalling pathway.

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Published

12-12-2025

How to Cite

Zhou Qinghui, Chew Weiyun, Tang Hanqing, & Suresh V Chinni. (2025). The Role of The EphrinB2-EphB4 Bidirectional Signalling on Bone Remodeling: A Review. Malaysian Journal of Science (MJS), 44(sp1), 1–7. https://doi.org/10.22452/mjs.vol44sp1.1

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Vol. 44 No. sp1 (2025): Special Issue: MAHSA International Medical Sciences and Technology Conference (Mi-Med) 2024

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Special Issue - Mi-Med 2024

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