Synthesis and Biological Properties of Zinc(II)Complexes of some 2-hydroxyacetophenone-benzoylhydrazones

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Hapipah M. Ali
Siti Nadiah Abdul Halim
Subramaniam P
Zain S.M
Jefri Basirun W
Endom Ismail
Noorlidah Abdullah
Teoh H.L

Abstract

The new zinc(II) complexes have been prepared in ethanol by condensation of 2-hydroxyacetophenone with either benzhydrazide or 3-methoxybenzhydrazide and zinc acetate in the presence of triethylamine. The IR, ¹H, ¹³C NMR and UV-visible data show coordination of hydrazone ligands to the metal centers and the spectroscopic data augur well with the x-ray structures which had been published earlier. The Schiff bases and their complexes were screened for antimicrobial, cytotoxic and antioxidant activities. The anti-microbial activities of the ligands and complexes were evaluated by using plate diffusion method against some gram-positive bacteria, gram-negative bacteria and two fungi. There was growth inhibition exhibited by ligands and zinc(II) complexes against tested bacteria and fungi. The Schiff base, Hâ‚‚hapbh was cytotoxic with ICâ‚…â‚€ 10.0 µgmlâ»Â¹ against the MCF-7 (human breast cancer cells) while both zinc(II) dimer complexes were strongly cytotoxic with ICâ‚…â‚€ values of 4.5 µgmlâ»Â¹. The Schiff bases and zinc(II) complexes showed higher antioxidant activity than quercetin or vitamin E and is comparable with butylated hydroxy toluene (BHT), a commercially used synthetic antioxidant.

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How to Cite
M. Ali, H., Abdul Halim, S. N., P, S., S.M, Z., W, J. B., Ismail, E., Abdullah, N., & H.L, T. (2006). Synthesis and Biological Properties of Zinc(II)Complexes of some 2-hydroxyacetophenone-benzoylhydrazones. Malaysian Journal of Science, 25(2), 97–106. Retrieved from https://ejournal.um.edu.my/index.php/MJS/article/view/8134
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Original Articles