Immunoinformatics Analysis of Mojiang Virus G Protein Epitopes
DOI:
https://doi.org/10.22452/jtoh.vol1.5Keywords:
paramyxovirus, immunoinformatics, emerging zoonotic virusAbstract
Mojiang virus (MojV), a rodent-borne parahenipavirus, is closely related to Nipah and Hendra viruses. Located in the tropical–subtropical Asia emerging-disease hotspot, MojV highlights One Health risks at the wildlife–human interface amid land-use change and climate-driven reservoir shifts. With no vaccines or treatments available, we used immunoinformatics to identify conserved B- and T-cell epitopes in the attachment glycoprotein (G). Four high-scoring, non-toxic, non-allergenic epitopes were prioritised: B-cell epitope LGTGGGGYQVL (385–395), CTL epitope DTTIKPIEY (174–182), CTL/HTL epitope LRFGITPDISVRSTT (465–479), and HTL epitope KDEIWCIAITEGKKQ (572–586). These epitopes offer promising candidates for multiepitope vaccines, improved diagnostics, and cross-henipavirus research. This study provides a framework to support vaccine preparedness against understudied zoonotic threats in tropical and subtropical regions.
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Copyright (c) 2026 Mei-Liew Yvonne-Jing, Alya Athirah Binti Afinddi (Author)
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© 2026 Tropical Infectious Diseases Research & Education Centre (TIDREC). Journal of Tropical One Health is a diamond open access journal. Articles published are licensed under a Creative Commons Attribution Non-commercial 4.0 International License (CC BY-NC 4.0) and are freely available to download, save, reproduce, and transmit strictly for non-commercial, scholarly, and educational purposes only. Reproduction and transmission of content for the above purposes are permitted with the condition that the author(s) and all original sources are duly credited. Permission must be obtained from the Tropical Infectious Diseases Research & Education Centre (TIDREC) prior to the use, reproduction, or distribution of content for commercial purposes.
